Hi Bernadette72,
I had the same problem very recently. I bought my ipad3 a few days ago and although it was very easy to set up my Gmail account, I had to manually set up my own email business account. Everything seemed fine until yesterday when I replied to emails they were being rejected by the server and placed in the outbox. Very frustrating because my only solution was to remove the account and set up again. So far so good but I am not holding my breath. Unfortunately, it appears that iPad software will not allow my account to use SSL and I had to set it up without it. Hope this helps.
Mike