As much as I complain about iOS, it does have quite a few strong points.
All I really want to see from iOS5 is more freedom to do things a little differently.
1) Widgets. Why does Apple seem to be so against widgets? We've all got this screen real estate and multiple home screens I can swipe through, why not let me put something more useful than an icon or a folder on each one?
2) Flash - yes it's been beaten to death, it's just another freedom thing. The iPad is capable of running some Flash content, so let me choose if I want to run it or not.
3) Better multitasking - load YouTube videos in the background please. Save my last state is ALL APPS, not just some.
I could go on for days about things I want changed, but realistically most of what I want probably isn't going to happen. I really have nothing personal against the iPad, I like how smooth everything is with it, I only get occasional crashing with apps. I just wish Apple would loosen the strings just a little bit and allow some deviation without resorting to jailbreaking (which doesn't even solve most of my wants anyways).