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Only if you want your iPad to sync music and other media from iTunes on the computer to your iPad, semi-automatically.
If you don’t sync the iPad with media on the computer, or prefer to do so manually using the USB cable; then leave it unchecked.
All I have are apps, e mails and favorites/bookmarks. No music or anything. Got a few books in i books.
Thanks for the reply..........Ken
One of the few things I absolutely need iTunes for is that some of the music, apps, and other iTunes content I’ve purchased over the years is no longer available through iTunes and has also been removed from my purchase history. In this special case, syncing with iTunes on my computer is necessary to transfer this content from the iTunes library on my computer to my iOS devices.