I find the iPad very simple to take notes on in any class. If I need to do more than typing, for example, if I need to draw a diagram, I'll type a quick note into my note taking program that says something like "see 12.2" and draw a diagram or picture on a regular piece of paper with a 12.2 written next to it. I find this is the smoothest way to do it for me, as I'm a science major, and most science diagrams involve a lot of little small text in odd places. So the iPad takes down the bulk of the information, and then I manually draw out anything I need to.