Ipad screen turned to negative colours

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You haven't inadvertently turned White on Black on have you? Have a look in Settings - General - Accessibility - White on Black and see if it's turned on here. If that's not ON have a look lower to Triple Click Home and what has been set up here, there are a few different options. This is activated by triple pressing the home button and is easy to activate by mistake. Hope this helps, let us know.

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Go to Settings>General>Accessibility and make sure that the Invert Colors switch is turned off. If that doesn't help, scroll down the page to the bottom and check Accessibility Shortcut to see if it's set to Invert Colors. If it is, a triple click of the home button will fix the Colors.