An interesting question. You may have seen another post that reports that the US FAA (Federal Aviation Administration) has just certified the iPad for in-flight use for pilots. Part of their evaluation included an 'explosive' decompression at 50,000'. So, I know that doesn't help you too much - I guess you're interested in pressure above atmospheric rather than below! If the application is work related, then I'd suggest to my employer that they invest in a second-hand iPad and try it out! But please report the results here....
Recently I was involved in a project for the oil industry, where we wanted to put some electronics in a pressurised container in an oil pipeline. The problem was that the ICs (silicon chips) are encapsulated in a ceramic package and the 'lid' to this package is hermetically sealed, with the inside pressure being atmospheric. In this particular case we were talking extreme pressures - several thousand psi. My own 'gut feeling' would be that it would be the screen that would pose the biggest problem - I wonder whether the various 'layers' that make up the screen are hermetically sealed?
Tim
Scotland