I'm having major issues at the moment, so everyone beware of the iOS 6.0.1 update!
It's killed my Bluetooth connectivity on both my iPad 2 and iPhone 3GS. The result is, no handsfree in my less than a month old car or connection to my less than a year old Bose speaker! I got away with not having any issues with iOS 6.0.0, but I've had a chunk bitten out of me this time!
I'm seriously unimpressed with Apple at the moment and considering defecting to Samsung for my next phone, as I can no longer tell people that I like Apple products, as "they always work"!
Shooting yourself in the foot Apple. Please take note and fix it ASAP.