We've all heard about probs with iOS 6, so I figure it'd be useful to have a thread dedicated to sharing tips on how to get the most out of it, especially for users who've upgraded and can't downgrade, or users who are hesitant to upgrade.
I'll paste some links to get things started, and maybe others can add tips, links and positive discoveries specific to iOS 6:
iPhone tips and tricks with iOS 6 - Pocket-lint
Top 10 Secret Features of iOS 6
iPhone User Guide for iOS 6 now available as an eBook | TUAW - The Unofficial Apple Weblog
Alternatives to iOS 6's Maps app | TUAW - The Unofficial Apple Weblog