I initially voted that lack of Flash was my biggest annoyance, but it is not the case with me anymore. I have found it does not matter like I thought. I use my desktop at home just as often, so it really ended up not mattering to me. But it has to do with my own personal use, and for others I can see their point. But yeah-we all know people got iPad knowing this. I knew it too, but had initially voted it anyway just because it was a WISH more than anything.
It's interesting to see a balanced viewpoint. This is an iPad forum, so I would expect people to mostly wax poetic about it. I am reading in this thread alone however absolute frustration, but the iPad still holds the interest if people are still taking the time to peruse the forum and post even if they are annoyed at the iPad specs for X,Y, or Z problem. But I get the OP's intent-OP just seemed to want to know specifics.